New Research Project Launches through SMCI’s Targeted Initiative Research Program

SMCI recently launched a new partnership as a component of our targeted initiative program, within our Pathways and Biomarkers Discovery Track. The project consists of original research in the areas of bioenergetics, metabolomics, and lipidomics using high-throughput technology. Importantly, this new SMCI research project relies on blood from well-qualified patients from The Levine Clinic; it also builds on recent discoveries in gut microbiome from Dr. Maureen Hanson’s lab, which uses these same patients.

As always, we partner with experts. In this instance, we have brought together the following group: Dr. Hanson, a professor of molecular biology and genetics at Cornell University; Dr. Levine, a member of SMCI’s Research Advisory Council and the chair of the Department of Health and Human Services Chronic Fatigue Syndrome Advisory Committee; and Metabolon, an industry leader in the discovery of biomarkers through the use of metabolomics (a “high-throughput technology” and a powerful scientific approach for the discovery and development of drugs and for early disease diagnosis).

Results from this new study have the potential to be quite significant and may include

  • Expanding the gut microbiome findings and providing additional context and clarity
  • Identifying specific biological signatures from well-characterized patients
  • Developing mechanistic insight into comorbidities associated with ME/CFS
  • Uncovering potential new biomarkers that could help with rapid and effective diagnosis
  • Comprehending signaling pathway interactions involved in the disease
  • Supporting existing projects and hypotheses by us and others as well as generating new hypotheses
  • Classifying patients based on molecular alterations
  • Developing precision medicine profiles, categories, and subcategories in ME/CFS with additional patients

We expect that the initial phase of this new project will be completed in the next quarter, with results requiring additional mechanistic investigation to establish findings as reproducible and validated targets.

Dr. Zaher Nahle, SMCI’s vice president for research and scientific programs, stated, “We could not be more excited about our partnership with Dr. Hanson, Dr. Levine, and Metabolon. We look forward to analyzing the metabolome of both early- and late-stage ME/CFS patients and their controls using Metabolon’s multiplex platforms. It is our hope that this study will reveal signatures and identifiers pointing toward biomarkers as well as a molecular basis for the disease and its subgroups. The results from this study will help us to hone or validate our hypotheses. And, what’s more, we will be able to seek new partnerships and assist the work of others by publishing these results alongside our collaborators.”

http://solvecfs.org/new-research-project-launches-through-smcis-targeted-initiative-research-program/

Facebook
Twitter
WhatsApp
Email

1 thought on “New Research Project Launches through SMCI’s Targeted Initiative Research Program”

  1. This strategy leaves out environmental exposures-exposomics and the person in their world model of research. So from where i stand this is too narrow and too presumptive. ME/CFS has baffled researchers for sometime- and so I think they need to give any research strategy a short opportunity before realizing its not working.
    They should embrace adaptive research and not assume that metabolomics or any omics or wet biomarker will be revealing. What biomarkers have been revealing for migraine or ostearthritis or even chronic pain? Lets not linger on fashionable research strategies if they dont lead to substantially better understanding and treatments or diagnoses.

Leave a Comment

Your email address will not be published.

Latest News

New Volunteer Leadership Program Led by Experts!

We are thrilled to announce that Chimére Smith and Terri Wilder will be joining #MEAction as consultants to execute a new volunteer leadership training program funded by the Ford Foundation! We are so thrilled that we will be able to expand our volunteer programs to include robust training and provide fulfilling roles and opportunities for

Read More »

Research Update: The NIH Intramural ME/CFS Study

National Institutes of Health researchers who began what may be the deepest biological investigation ever of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) are writing up their findings and plan to circulate a draft among their large team of scientists and physicians for feedback soon.  “The study will help patients and should move the field forward in

Read More »

#MEAction Meets with the Department of Labor

#MEAction continues our advocacy for the #MillionsMissing in a recent meeting with the Office of Disability Employment Policy (ODEP) at the U.S. Department of Labor (DOL) where we presented on community issues affecting people with ME and Long COVID and offered policy recommendations that DOL can take to address them. President Biden’s Memorandum tasks DOL

Read More »

Help keep our work going

We rely on donations from people like you to keep fighting for equality for people with ME.

Donate

Get actions alerts and news direct to your inbox

You can choose what you want to be kept up to date on.

Subscribe
Scroll to Top