NIH gives $246,000 for study of oral rehydration in ME/CFS patients with orthostatic intolerance

Share on facebook
Share on twitter
Share on email

The US National Institutes of Health (NIH) has announced a $246,000 grant to study the use of an oral solution of isotonic saline to reduce orthostatic intolerance (OI) in ME/CFS patients.
The grant has been awarded to New York Medical College’s Professor Marvin Medow, who has long had an interest in OI in ME/CFS, particularly in young people. The money comes via the National Institute of Neurological Disorders and Stroke (NINDS), which is the current leader of the ME/CFS trans-NIH Working Group at the NIH.
Most patients with ME/CFS have OI, defined as the inability to maintain an upright posture without developing symptoms. Patients whose heartrate increases excessively on standing have postural tachycardia syndrome (POTS), while those whose blood pressure falls excessively have neurally mediated hypotension (NMH).
Both are caused by a failure of the body’s normal ability to prevent too much blood being pulled by gravity from the brain and heart upon standing. The cause of OI in ME/CFS is unknown. Intravenous saline is an effective treatment but has risks if used long-term.
Usual methods of oral hydration have not been as effective but Professor Medows noticed that the isotonic oral rehydration solution (ORS) used by the World Health Organisation (WHO) is effective in rehydrating cholera patients, which suggested to him that it might be as good as, or better than intravenous saline for OI.
Professor Medow has already made preliminary physiological measurements of ME/CFS patients with OI that indicate that ORS is better than intravenous fluid in restoring orthostatic tolerance.
In the study, he and his team will examine the physiology of 15 ME/CFS POTS patients, 15 ME/CFS NMH patients and 15 healthy controls in response to both intravenous and oral fluid loading during orthostatic stress. Each participant will be rehydrated with each method a week apart, in random order.
The WHO ORS is a solution that includes glucose and sodium and is available online via, for example, Amazon (US). Recipes can also be found online. However, there are risks with taking on more fluid than the body is equipped to handle and this intervention should not be attempted without medical supervision.​
Professor Medow’s project is due to complete by January 2018.

Share on facebook
Facebook
Share on twitter
Twitter
Share on whatsapp
WhatsApp
Share on google
Google+
Share on email
Email

1 thought on “NIH gives $246,000 for study of oral rehydration in ME/CFS patients with orthostatic intolerance”

  1. Anything is worth a try but given that many people with ME/CFS suffer from new onset sugar intolerance, it appears less likely to help than predicted???
    Great to see some physiological research being done!!
    Now we’re waiting for the studies on our heart rate and how it reacts to exertion…. and trials on pacing using a heart rate monitor that many people are finding beneficial.

Leave a Comment

Your email address will not be published. Required fields are marked *

Latest News

Sign petition To Fix ME/CFS tracking In US!

In August, we shared with you that we and six other ME/CFS organizations had submitted a proposal to the National Center of Health Statistics (NCHS) to fix the coding of ME/CFS in the US International Classification of Diseases (ICD-10-CM). Today, we are writing with an update on that proposal and asking that you sign the

Read More »

NICE announces roundtable event to ensure implementation of ME/CFS guideline

NICE announced today that it will hold a roundtable in September as the next step in the publication of the ME/CFS guideline. The roundtable will include representatives from patient organisations and charities, relevant professional societies, NHS England and NHS Improvement, NICE and the guideline committee. It aims to, “better understand the issues raised and determine

Read More »

#MEAction & 6 ME Orgs Call for CDC to Change How it Tracks ME/CFS

Together with six other organizations, we have submitted a proposal to the National Center for Health Statistics (NCHS) to add myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) to the neurological chapter of the International Classification of Diseases (ICD-10-CM).  Today, ME/CFS does not exist in the US ICD-10-CM. Instead,  most US doctors assign the code for chronic fatigue

Read More »

Help keep our work going

We rely on donations from people like you to keep fighting for equality for people with ME.

Donate

Get actions alerts and news direct to your inbox

You can choose what you want to be kept up to date on.

Subscribe
Scroll to Top