David Tuller wrote an in-depth, investigative piece on the methodological flaws and irregularities of the PACE trial, a UK study and, at £5 million, the most expensive study of ME/CFS in history. Its authors claimed – based on subjective outcome measures that were contradicted by more reliable, objective measures – that ME/CFS patients improve with graded exercise therapy (GET) and cognitive behavioral therapy (CBT). The study authors continue to maintain that GET and CBT are effective treatments, despite the fact that their long-term follow-up study shows a null effect.
Note this page is no longer being maintained. For a more complete background on the PACE trial see: the PACE trial page on MEpedia.org.
“Uninterpretable: Fatal flaws in PACE Chronic Fatigue Syndrome follow-up study,” James Coyne, PLOS Blogs