Covid-19 Resources for People with ME


PACE Trial: Overview

David Tuller wrote an in-depth, investigative piece on the methodological flaws and irregularities of the PACE trial, a UK study and, at £5 million, the most expensive study of ME/CFS in history. Its authors claimed – based on subjective outcome measures that were contradicted by more reliable, objective measures – that ME/CFS patients improve with graded exercise therapy (GET) and cognitive behavioral therapy (CBT). The study authors continue to maintain that GET and CBT are effective treatments, despite the fact that their long-term follow-up study shows a null effect.​

Note this page is no longer being maintained. For a more complete background on the PACE trial see: the PACE trial page on

#MEAction PACE trial petition
2011 PACE trial
David Tuller’s investigation of the 2011 PACE trial
Sharpe and White’s 2015 follow up study on the PACE trial